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Sodium fluoride is an inorganic compound widely utilized in biomedical research for its inhibitory action on enzymes involved in cellular metabolism particularly enolase within the glycolytic pathway By inhibiting glycolytic activity sodium fluoride disrupts ATP production making it a valuable tool for assessing metabolic processes in vitro It is commonly employed to prevent glycolysis in blood samples for biochemical assays and in studies investigating metabolic regulation cellular energetics and mechanisms of fluoride toxicity Sodium fluoride s modulation of metabolic enzymes supports its use in mechanistic studies of cell physiology and metabolic control
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L-Phenylephrine (CAS 59-42-7) is a selective agonist of the adrenergic 1A receptor exhibiting a Ki of 1 4 M with markedly lower affinity for 1B (Ki 23 9 M) and 1C (Ki 47 8 M) subtypes In vitro L-Phenylephrine has been shown to reduce apoptosis in neonatal rat cardiomyocytes following hypoxia and serum deprivation and to stimulate proliferation in neural progenitor cells It also increases the cross-sectional area and modulates gene expression in rat neonatal cardiomyocytes In vivo local administration in rats induces cutaneous anesthesia through 1-adrenergic receptor activation and clinical data suggest oral administration reduces nasal airway resistance These properties make L-Phenylephrine a valuable tool for studying 1A-adrenergic receptor-mediated cellular responses
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Mefenamic acid (CAS 61-68-7) is a non-steroidal anti-inflammatory compound that acts by inhibiting cyclooxygenase (COX) enzymes leading to decreased synthesis of prostaglandins involved in inflammation and pain signaling It is extensively studied for its ability to modulate inflammatory pathways and is commonly utilized as a pharmacological tool in research focused on pain mechanisms inflammatory responses and prostaglandin-mediated processes Mefenamic acid is often employed in in vitro and in vivo models to evaluate the effects of COX inhibition on physiological and pathological conditions
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